Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids
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چکیده
منابع مشابه
Chaplins of Streptomyces coelicolor self-assemble into two distinct functional amyloids.
Chaplins are small, secreted proteins of streptomycetes that play instrumental roles in the formation of aerial hyphae and attachment of hyphae to surfaces. Here we show that the purified proteins self-assemble at a water/air interface into an asymmetric and amphipathic protein membrane that has an amyloid nature. Cryo-tomography reveals that the hydrophilic surface is relatively smooth, while ...
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The self-association of proteins into amyloid fibrils offers an alternative to the natively folded state of many polypeptides. Although commonly associated with disease, amyloid fibrils represent the natural functional state of some proteins, such as the chaplins from the soil-dwelling bacterium Streptomyces coelicolor, which coat the aerial mycelium and spores rendering them hydrophobic. We ha...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2013
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2013.08.013